New Antibiotic Development Outpaced by Drug Resistance Challenges

Zachary Lutsky, MD, is a respected emergency physician in the Los Angeles area. Among the fields in which Dr. Zachary Lutsky has an extensive interest is antibiotic over-prescription and the resulting disease resistance to traditional drugs.

A recent report from the Access to Medicine Foundation, “Antimicrobial Resistance Benchmark,” found that the issue of antibiotic resistance is still not addressed adequately, with annual related global deaths exceeding 700,000.

Unfortunately, with resistance increasing to existing drugs, pharmaceutical companies in general are not keeping pace with the problem by developing new antibiotics. This has to do with a combination of high research-and-development costs and relatively small profits for approved products.

A number of companies, however, are continuing to explore new pathways, with Johnson & Johnson reporting that, while it has ended research on traditional antibiotics, it is putting efforts into novel antibacterial vaccines. In total, 54 drugs that work against bacterial and fungal infections are in various clinical development stages worldwide, with 51 considered safe enough for Phase II studies involving humans.

Treatment of Diabetes – Possible Side Effects of Excess Insulin

A graduate of a doctor of medicine degree in emergency medicine from Harbor-UCLA Medical Center in California, Zachary Lutski is a former emergency physician at Cedars-Sinai Medical Center. With 11 years of work experience at Cedars-Sinai Medical Center, Zachary Lutski has worked with patients suffering from emergency medical conditions, including stroke and heart attack.

While it has been the leading cause of death all over the world for many years, cardiovascular disease is generally defined as any condition that involves blocked or narrowed blood vessels, which can result in heart attack or stroke. Obesity, high cholesterol level, and diabetes are commonly associated with heart attack. In the United States, about 1.4 million heart attacks are reported each year.

Although lack of enough insulin in the body can result in diabetes, which is one of the leading causes of heart attack, a team of researchers in Japan recently discovered that using insulin as a therapy to treat diabetes could be detrimental to patients’ health if patients are also suffering from chronic high blood pressure.

Led by Issei Komoru at Chiba University Graduate School of Medicine in Japan, the research was conducted on mice. In one of the experiments done in the research, excess insulin was introduced into the system of type 1 diabetic mice. They discovered that there was an increase in heart failure in the mice, though blood glucose levels were stabilized. This result indicated that although chronic high blood pressure causes liver cell resistance to insulin, it also amplifies insulin signaling in the heart.

At the end of the study, results suggested that insulin treatment could be dangerous to the health of chronic high blood pressure patients when insulin is administered at a high level. Therefore, maintaining a normal level of insulin is crucial to the success of insulin therapy.

Common Symptoms of a Heart Attack

Preparing for the 2019/20 Flu Season

Over the course of his decade-long career, Dr. Zachary Lutsky has worked at top-of-the-line medical centers across California. As an emergency physician for the Cedar-Sinai trauma center, Dr. Zachary Lutsky has encountered patients needing immediate care due to influenza-related complications.

Every flu season, the World Health Organization publishes frequently updated information about the most prevalent strains of influenza and areas where transmission rates are high. At the start of the 2019 season, influenza rates increased in many parts of the world, including the Middle East, West Africa, and Central America.

In the US, several fatal cases had already been reported. According to the Center for Disease Control (CDC), the 2019 vaccine is a good match for the most commonly reported flu strains. Along with most medical professionals, The CDC advises anyone older than 6 months old to be inoculated against the flu at least 6 weeks prior to the start of the flu season, which starts in October in the US.