Tag Archives: diabetes

Treatment of Diabetes – Possible Side Effects of Excess Insulin

A graduate of a doctor of medicine degree in emergency medicine from Harbor-UCLA Medical Center in California, Zachary Lutski is a former emergency physician at Cedars-Sinai Medical Center. With 11 years of work experience at Cedars-Sinai Medical Center, Zachary Lutski has worked with patients suffering from emergency medical conditions, including stroke and heart attack.

While it has been the leading cause of death all over the world for many years, cardiovascular disease is generally defined as any condition that involves blocked or narrowed blood vessels, which can result in heart attack or stroke. Obesity, high cholesterol level, and diabetes are commonly associated with heart attack. In the United States, about 1.4 million heart attacks are reported each year.

Although lack of enough insulin in the body can result in diabetes, which is one of the leading causes of heart attack, a team of researchers in Japan recently discovered that using insulin as a therapy to treat diabetes could be detrimental to patients’ health if patients are also suffering from chronic high blood pressure.

Led by Issei Komoru at Chiba University Graduate School of Medicine in Japan, the research was conducted on mice. In one of the experiments done in the research, excess insulin was introduced into the system of type 1 diabetic mice. They discovered that there was an increase in heart failure in the mice, though blood glucose levels were stabilized. This result indicated that although chronic high blood pressure causes liver cell resistance to insulin, it also amplifies insulin signaling in the heart.

At the end of the study, results suggested that insulin treatment could be dangerous to the health of chronic high blood pressure patients when insulin is administered at a high level. Therefore, maintaining a normal level of insulin is crucial to the success of insulin therapy.